Obviously I was exaggerating. Sheesh.
Hotels will love it, and so will some places like restaurants and such. I'd guess that the vast majority of Tampons don't. If you have a job anywhere near downtown Tampa, look forward to your 15-minute commute taking 2 hours, with random checkpoints and road closures. A lot of people I know are just going on vacation next week.
The Hard Rock Casino will love it, because someone with the RNC booked the entire casino for the whole week. Irony...